Monteiro CA, Moubarac JC, Cannon G, Ng SW, Popkin B. AWHS, Aragon Workers’ Health Study CACS, Coronary Agatston Calcium Score UPF, ultra-processed food OR, odds ratio CI, confidence interval Models adjusted for age, marital status, education, smoking, physical activity, sleep duration during weekdays and during the weekend, alcohol consumption, total fiber intake, cholesterol intake, total energy intake, and cardiovascular risk factors: total serum cholesterol, HDL serum cholesterol, systolic and diastolic blood pressure, body mass index, and diabetes. a The odds of CACS > 0 ( p value of the Wald test for non-linearity is 0.59) and b the odds of CACS > 100 ( p value of the Wald test for non-linearity is 0.029) as ultra-processed food consumption increases. The histograms show the distributions of energy-adjusted ultra-processed food consumption. Participants with an exposure above the 99th percentile were not included. The standard binary logistic regression was used to perform restricted cubic splines with 3 knots of the distribution (at the 10th, 50th, and 90th percentiles of the distribution). Restricted cubic splines for the association of Coronary Artery Calcium (CACS) and ultra-processed food (UPF) consumption, in the AWHS cohort study ( N = 1876). In this middle-aged worker's sample, approximately 500 g/day of UPF consumption was associated with a 2-fold greater prevalence of subclinical coronary atherosclerosis than consuming only 100 g/day, independently of total energy intake and other well-established cardiovascular risk factors.Ĭoronary calcium Cross-sectional cohort study Nutritional epidemiology Subclinical coronary atherosclerosis Ultra-processed food. The fully adjusted ORs (95% CI) of having a CACS ≥ 100 across quartiles of energy-adjusted UPF consumption (approximately 100 g/day in the lowest quartile (ref.) and 500 g/day in the highest) were 1.00 (ref.), 1.50 (0.93, 2.42), 1.56 (0.96, 2.52), and 2.00 (1.26, 3.16), p trend. Associations between consumption of total energy-adjusted UPF and Coronary Calcium Agatston Score (CACS)-categorized into CACS of 0, > 0 and 0 and < 100). UPF was defined according to the NOVA classification. Dietary intake was collected by a validated 136-item semi-quantitative food frequency questionnaire.
#High consumption free#
All participants were free of coronary heart disease.
We aimed to assess whether consumption of UPF is directly associated with subclinical coronary atherosclerosis in middle-aged men.Ī computed tomography scan was performed on 1876 men from the Aragon Workers' Health Study, recruited from January 2011 to December 2014, to assess coronary calcium. Ultra-processed food (UPF) consumption, which is increasing worldwide, has recently been associated with an increased risk of death and cardiovascular disease. 14 IMDEA-Food Institute CEI UAM+CSIC, Madrid, Spain.13 Instituto de Investigación IdiPaz, Madrid, Spain.12 CIBERESP (CIBER of Epidemiology and Public Health) Instituto de Salud Carlos III, Madrid, Spain.11 Agencia Aragonesa para la Investigación y el Desarrollo (ARAID), Zaragoza, Spain.
Chan School of Public Health, Boston, MA, USA. 10 Department of Nutrition, Harvard T.H.9 Department of Microbiology, Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain.8 CIBERCV Instituto de Salud Carlos III, Madrid, Spain.7 IIS Aragón, Hospital Universitario Miguel Servet, Universidad de Zaragoza, Zaragoza, Spain. 6 IMDEA-Food Institute CEI UAM+CSIC, Madrid, Spain. 5 Instituto de Investigación IdiPaz, Madrid, Spain. 4 CIBERESP (CIBER of Epidemiology and Public Health) Instituto de Salud Carlos III, Madrid, Spain. 3 Unit of Nutritional and Cardiovascular Epidemiology, Environmental Medicine Institute (IMM), Karolinska Institutet, Stockholm, Sweden. Arzobispo Morcillo, n 4, 28029, Madrid, Spain. 2 Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, CEI UAM+CSIC, Avda.1 Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, CEI UAM+CSIC, Avda.
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